Theta Burst Services


Welcome to information about the latest TBS protocol which promises to be dramatically more effective and long-lasting than regular rTMS

Theta Burst Stimulation

TBS has been found to be very helpful in treatment-resistant depression. The treatment involves the application of a burst of 50Hz pulses given 5 times per second (5Hz). The magnetic coils is placed over the left dorsolateral prefrontal cortex. Because this is a rapidly evolving area of research, we provide an input port on our generator for researchers, in the future, to inject their own pulse sequences, yet to be devised.


References

Three-minutes of theta-burst therapy can help conquer depression, Jan 2015, at http://www.ctvnews.ca/health/three-minutes-of-theta-burst-therapy-can-help-conquer-depression-1.2205080

While the old form of treatment took up to 40 minutes per session, high-frequency theta-burst stimulation takes only three minutes per day. The theta frequency is a frequency that the brain operates at when it’s learning new things and when it’s changing. So it capitalizes on the principle of neuroplasticity

Efficacy of prefrontal theta-burst stimulation in refractory depression, July 2014, at http://www.ncbi.nlm.nih.gov/pubmed/24817188

Safety and tolerability of theta burst stimulation vs. single and paired pulse transcranial magnetic stimulation: a comparative study of 165 pediatric subjects, Feb 2015, at http://journal.frontiersin.org/article/10.3389/fnhum.2015.00029/abstractCcomparative analysis showed that TBS appears to be as safe as TMS for children.

Theta-burst transcranial magnetic stimulation in depression: when less may be more, May 2014, at http://brain.oxfordjournals.org/content/early/2014/05/14/brain.awu123

High frequency (e.g. 10 Hz) repetitive TMS applied to the left dorsolateral prefrontal cortex is an FDA approved treatment for adults with resistant depression. In intermittent TBS, a 2-second train of TBS is delivered every 10 seconds. In this issue of Brain, Li et al. (2014) provide the first direct evidence that intermittent TBS applied to the left dorsolateral prefrontal cortex or a combination of intermittent plus continuous TBS applied to the left and right dorsolateral prefrontal cortex, respectively, are significantly more effective than continuous TBS or sham TBS in treatment-resistant depression. Response rates after 10 treatment sessions were 40% for intermittent TBS and 66.7% for the combination of intermittent plus continuous TBS—considerably higher than those reported in the high frequency repetitive TMS studies. This greater efficacy is reason enough to be encouraged by these findings. However, there are several other reasons. First, this study demonstrates that intermittent TBS can be applied safely and effectively over a much shorter time period (10 min versus 40 min using traditional high frequency approaches)